Metabolic

US FDA: A product contains HFCS as an added nutritive sweetener; FDA also states the Dietary Guidelines recommend limiting added sugars including HFCS and sucrose.

US FDA: The US FDA listed by public Q&A that sucralose is approved for use in food as a sweetener. World Health Organization: WHO flagged by guideline announcement the non-sugar-sweetener category, including sucralose, for weight-control use; applicability is class-level guidance, not an ingredient-specific market ban.

eCFR / US FDA: The US lists acesulfame potassium under 21 CFR 172.800 as a general-purpose sweetener and flavour enhancer subject to conditions of use. World Health Organization: WHO flagged by guideline announcement the non-sugar-sweetener category, including acesulfame K, for weight-control use; applicability is class-level guidance, not an ingredient-specific market ban.

Nature Medicine: Nature Medicine authors reported that circulating erythritol was associated with incident 3-year major adverse cardiovascular events in cardiac-evaluation cohorts; limitation: observational association plus mechanistic substudies, not a product-level causal finding.

US FDA: The US FDA listed by public sweeteners Q&A that saccharin is currently approved for use under certain conditions in beverages, tabletop substitute use, and processed foods. US FDA: FDA flagged by public Q&A the historical saccharin bladder cancer rat-labeling story and the 2000 NTP removal from the list of potential carcinogens; applicability is historical context, not a current warning-label rule.

US FDA: A product contains high-purity steviol glycosides in the FDA-described plant-based sweetener category; FDA says it has evaluated many GRAS notices for 95% minimum purity steviol glycosides.